The Patient-Centered Primary Care Collaborative has published its fifth annual review of the evidence in its 2016 edition of The Patient-Centered Medical Home’s Impact on Cost and Quality. The report reviews 17 peer-reviewed studies, 4 state government evaluations, 7 industry reports, and 3 independent evaluations of large federal patient-centered medical home (PCMH) initiatives published between October 2014 and November 2015. The report also highlights 30 primary care PCMH initiatives from around the country that measured cost and utilization of services, and includes an analysis of the findings. The report also describes the payment model for each initiative and the implications of Medicare payment reform. The report concludes with a call for comprehensive payment reform, alignment of payment and performance measurement, and a unified multi-stakeholder voice that speaks to the importance of alternative payment reforms to support the PCMH model. The report was funded by the Milbank Memorial Fund.