This discussion paper from participants in the Institute of Medicine Roundtable on the Promotion of Health Equity and the Elimination of Health Disparities raises the question of whether the patient-centered medical home model adequately addresses the social determinants of health that will drive long-term improvements in population and community health. The authors argue that while reliance solely on improvements in health care delivery may result in short-term improvements in health status, longer-term and sustained population-level improvements in health status require medical providers, whether they are or not structured as patient-centered medical homes, to be more proactive in working with patients, families, and communities to address those social determinants. The authors suggest opportunities for patient-centered medical homes to explicitly form partnerships and linkages with other service providers working on those broader issues of housing, education, employment, violence, and social opportunity.