This issue brief from The Commonwealth Fund uses data from its 2010 Biennial Health Insurance Survey to demonstrate that when low-income adults have both health insurance and a medical home they are less likely to report cost-related access problems, more likely to be up-to-date with preventive screenings, and report greater satisfaction with the quality of their health care. Most important, gaps in health care between these low-income populations and higher-income populations are significantly reduced for those with both health insurance and a medical home. The issue brief concludes that, along with health insurance coverage expansions, it will be important for public and private stakeholders to create opportunities that enhance access to medical homes for vulnerable populations.